Yang Lab

Department of Biochemistry Brandeis University

Publications

Working! 😊

Publications Prior to Brandeis

High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs
Carroll, E. C.; Yang, H.; Powell, W. C.; Charvat, A. F.; Oehler, A.; Jones, J. G.; Montgomery, K. M.; Yung, A.; Millbern, Z.; Taylor, A. I. P.; Wilkinson, M.; Ranson, N. A.; Radford, S. E.; Vinueza, N. R.; DeGrado, W. F.; Mordes, D. A.; Condello, C.; Gestwicki, J. E.
Nat. Chem. 2025, ASAP
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SuFEx Chemistry Enables Covalent Assembly of a 280-kDa 18-Subunit Pore-Forming Complex
Schnaider, L.; Tan, S. L.; Singh, P.; Capuano, F.; Scott, A.; Hambley, R.; Lu, L.; Yang, H.; Wallace, E.; Jo, H.; DeGrado, W. F.
J. Am. Chem. Soc. 2024, 146, 25047–25057
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Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer’s Disease Fold
Ghosh, U.*; Tse, E.*; Yang, H.; Shi, M.; Caro, C. D.; Wang, F.; Merz, G. E.; Prusiner, S. B.; Southworth, D. R.; Condello, C.
Acta Neuropathol. Commun. 2024, 12, 94
pubmed |html |pdf |PDB 9BXI |PDB 9BXO |PDB 9BXQ |PDB 9BXR
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De novo Design of Peptides that Bind Specific Conformers of α-Synuclein
Wallace, H. M.*; Yang, H.*; Tan, S. K.; Pan, H. S.; Yang, R.; Xu, J.; Jo, H.; Condello, C.; Polizzi, N. F.; DeGrado, W. F.
Chem. Sci. 2024, 15, 8414–8421
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Supramolecular Interactions of Teixobactin Analogues in the Crystal State
Yang, H.; Kreutzer, A. G.; Nowick, J. S.
J. Org. Chem. 2024, 89, 5104–5108
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De novo design of drug-binding proteins with predictable binding energy and specificity
Lu, L.; Gou, X.; Tan, S.; Mann, S. I.; Yang, H.; Zhong, X.; Jo, H.; Wu, Y.; Diolaiti, M.; Ashworth, A.; Polizzi, N. F.; DeGrado, W. F.
Science 2024, 384, 106–112
pubmed |html |PDB 8TN1 |PDB 8TN6 |PDB 8TNB |PDB 8TNC |PDB 8TND
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EMBER multi-dimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains
Yang, H.; Yuan, P.; Wu, Y.; Shi, M.; Caro, C. D.; Tengeiji, A.; Yamanoi, S.; Inoue, M.; DeGrado, W. F.; Condello, C.
Proc. Natl. Acad. Sci. U.S.A. (PNAS) 2023, 120, e2300769120
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Covalent labeling of a chromatin reader domain using proximity-reactive cyclic peptides
Zhang, M. Y.; Yang, H.; Ortiz, G.; Trnka, M. J.; Petronikolou, N.; Burlingame, A. L.; DeGrado, W. F.; Fujimori, D. G.
Chem. Sci. 2022, 13, 6599–6609
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Exploration of α/β/γ-peptidomimetics design for BH3 helical domains
Shin, Y. H.; Yang, H.
Chem. Commun. 2022, 58, 945–948
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Microbowls with controlled concavity for accurate microscale mass spectrometry
Xu, L.; Li, X.; Li, W.; Chang, K.; Yang, H.; Tao, N.; Zhang, P.; Payne, E.; Modavi, C.; Humphries, J.; Lu, C.; Abate, A. R.
Adv. Mater. 2021, 34, 2108194
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An Aza-Diels–Alder Route to Quinoline-Based Unnatural Amino Acids and Polypeptide Surrogates
Umerani, M. J.; Yang, H.; Pratakshya, P.; Nowick, J. S.; Gorodetsky, A. A.
RSC Adv. 2021, 11, 14132–14139
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Dual antagonists of α5β1/αvβ1 integrin for airway hyperresponsiveness
Sundaram, A.; Chen, C.; Reed, N. I.; Liu, S.; Yeon, S. K.; McIntosh, J.; Tang, Y. Z.; Yang, H.; Adler, M.; Beresis, R.; Seiple, I. B.; Sheppard, D.; DeGrado, W. F.; Jo, H.
Bioorg. Med. Chem. Lett. 2020, 30, 127578
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Design, Synthesis, and Study of Lactam and Ring-Expanded Analogues of Teixobactin
Yang, H.; Pishenko, A. V.; Li, X.; Nowick, J. S.
J. Org. Chem. 2020, 85, 1331-1339
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X-ray Crystallographic Structure of a Teixobactin Derivative Reveals Amyloid-like Assembly
Yang, H.; Wierzbicki, M.; Du Bois, D. R.; Nowick, J. S.
J. Am. Chem. Soc. 2018, 140, 14028-14032
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X-ray Crystallographic Structure of a Teixobactin Analogue Reveals Key Interactions of the Teixobactin Pharmacophore
Yang, H.; Du Bois, D. R.; Ziller, J. W.; Nowick, J. S.
Chem. Commun. 2017, 53, 2772-2775
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Elucidation of the Teixobactin Pharmacophore
Yang, H.; Chen, K. H.; Nowick, J. S.
ACS Chem. Biol. 2016, 11, 1823–1826
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