Fingerprinting Strains of Amyloids in Neurodegenerative Diseases

We develop experimental and computational approaches to distinguish amyloid polymorphs (conformational strains) and link structure to biological activity.

Designing De Novo Proteins with Predictable Function

We design peptides and proteins that assemble into higher-order architectures with tunable symmetry, stability, and function.

Studying  Peptides and Peptidomimetics with Target Function 

We study how conformational heterogeneity and dynamics impact binding and assembly, informing design principles for functional peptides and peptidomimetics.